Two enzymes involved in the synthesis of pyrimidine and purine nucleotides, CTP synthase (CTPS) and IMP dehydrogenase (IMPDH), can assemble into a single or very few large filaments called rods and rings (RR) or cytoophidia. Most recently, asymmetric cytoplasmic distribution of organelles during cell division has been described as a decisive event in hematopoietic stem cell fate. We propose that cytoophidia, which could be considered as membrane‐less organelles, may also be distributed asymmetrically during mammalian cell division as previously described for (...) Schizosaccharomyces pombe. Furthermore, because each type of nucleotide intervenes in distinct processes (e.g., membrane synthesis, glycosylation, and G protein‐signaling), alterations in the rate of synthesis of specific nucleotide types could influence cell differentiation in multiple ways. Therefore, we hypothesize that whether a daughter cell inherits or not CTPS or IMPDH filaments determines its fate and that this asymmetric inheritance, together with the dynamic nature of these structures enables plasticity in a cell population. (shrink)

In many areas, technology has facilitated many things, diagnosing diseases, regulating traffic and teaching students in schools rely on Intelligent systems to name a few. At present, traditional classroom-based education is no longer the most appropriate in schools. From here, the idea of intelligent e-learning for students to increase their culture and keep them updated in life began. E-learning has become an ideal solution, relying on artificial intelligence, which has a footprint in this through the development of systems based on (...) education without a teacher taking into account the individual differences of students. This study describes intelligent tutoring system for teaching the Data Manipulation Language (DML) Commands Using SQLite to non IT students to overcome the difficulties they face. The System was built as education system by using the researcher own authoring tool that based on mobile and web App. The basic idea of this system is a systematic introduction into the concept of Database and its DML query. The system presents the topic of DML Commands, help student to execute what they are learn from the system content using the practical part of the system and administers automatically adapted at run time to the student’s individual growth. The system was assessed by a group of teachers and students and the outcome showed as 91% from the database specialists, 94% from Diploma students group and 89% from the secondary school students group. (shrink)

Backed by its technological achievements, modern science appears as the de facto source of truth to the majority of our contemporaries. Its sole reliance on reason and empirical data gives it an air of objectivity that has conferred upon it an almost unquestioning authority. Against the backdrop of this pervasive scientism, Philosophy of Science in the Light of the Perennial Wisdom is a daring attempt to offer an intellectual critique of modern science in its foundation by rigorously examining the intrinsic (...) limitations of rational thought and empirical investigation. Unique of its kind, this book offers a refreshing look at the traditional doctrines of epistemology and metaphysics as an antidote to the subjective as well as objective errors of modern science, which is thus revealed as no more than a belief system that falls radically short of offering a full knowledge of reality; this, in contrast to the perennial wisdom of the world's great religions that for millennia have offered humankind not only keys to true knowledge, but also the means of attaining it, which precisely constitutes man's reason for being. (shrink)

Physicist Percy Bridgman has been taken by Heather Douglas to be an exemplar defender of an untenable value-free ideal for science. This picture is complicated by a detailed study of Bridgman's philosophical views of the relation between science and society. The normative autonomy of science, a version of the value-free ideal, is defended. This restriction on the provenance of permissible values in science is given a basis in Bridgman's broader philosophical commitments, most importantly, his view that science is primarily an (...) individual commitment to a set of epistemic norms and values. Considerations of external moral or social values are not, on this view, intrinsic to scientific practice, though they have a broader pragmatic significance. What Bridgman takes as the proper relation between science and society is shown through analysis of his many writings on the topic and consideration of his rarely remarked upon involvement in the most problematic example of "Big Science" of his day: the atomic bomb. A reevaluation of Bridgman's views provides a unique characterization of what is at stake in the values in science debate: the normative autonomy of science. (shrink)

Despite the increasingly diversified discourses in international commercial arbitration, this device of socio-legal regulation remains a relatively under-theorized subject. In particular, far too little attention has been paid to analyzing international commercial arbitration through critical approaches such as Third World Approaches to International Law (TWAIL). TWAIL is broadly understood as a methodological reorientation in international law by highlighting the historical links between the foundations of this field of law and the history of capitalism and imperialism as well as the colonial (...) and Eurocentric legacies in the structure and operation of the current international legal regime. With this in mind, two fronts in international commercial arbitration invite a reexamination through a TWAIL perspective and by drawing on the concept of hegemony. One front is the transnational account of arbitration, and the other one is the epistemic community of arbitration. By examining these two notions through a narrative of hegemony of Western legal traditions, we posit that any effective attempt at redefining or reforming arbitral governance structure towards sustaining diversity requires a deeper understanding of historical and current world power structures and creating a vision for the prospect of dehegemonization. (shrink)

Given the evolution of the public health (PH) and the changes from the phenomenon of globalization, this area has encountered new ethical challenges. In order to find a coherent approach to address ethical issues in PH policy, this study aimed to identify the evolution of public health ethics (PHE) frameworks and the main moral values and norms in PH practice and policy. According to the research questions, a systematic search of the literature, in English, with no time limit was performed (...) using the main keywords in databases Web of Science (ISI) and PubMed. Finally, the full text of 56 papers was analyzed. Most of the frameworks have common underpinning assumptions and beliefs, and the need to balance PH moral obligation to prevent harm and health promotion with respect for individual autonomy has been specified. As such, a clear shift from liberal values in biomedical ethics is seen toward the community’s collective values in PHE. The main moral norms in PH practice and policy included protecting the population against harm and improving PH benefits, utility and evidenced-based effectiveness, distributive justice and fairness, respect for all, privacy and confidentiality, solidarity, social responsibility, community empowerment and participation, transparency, accountability and trust. Systematic review of PHE frameworks indicates utilization of the aforementioned moral norms through an practical framework as an ethical guide for action in the PH policy. The validity of this process requires a systematic approach including procedural conditions. (shrink)

In the past decade, the use of the Chapter XI has soared to the detriment of many creditors, workers, and consumers. A good number of cases were not based on imminent insolvency, but on firms attempts to avoid litigation claims against them, to terminate labor or other contractual obligations, or to gain new financing.These filings for Chapter XI highlight the use of bank-ruptcy as a strategic option used by management in running a viable organization. This usage is even advised by (...) some academics and management consultants. (shrink)

Are immigration restrictions compatible with liberalism? Recently, Freiman and Hidalgo have argued that immigration restrictions conflict with the core commitments of liberalism. A society with immigration restrictions in place may well be optimal in some desired respects, but it is not liberal, they argue. So if you care about liberalism more deeply than you care about immigration restrictions, you should give up on restrictionism. You can’t hold on to both. I argue here that many restrictions on contractual, economic, and associational (...) liberties seem to be justified by considerations other than liberty – thus the task for Freiman and Hidalgo is to tell us why such restrictions are justified but immigration restrictions are not. Moreover, even if this worry can be addressed, I argue, liberalism is not committed to its own demise in scenarios where there exist large enough numbers of would-be immigrants who accept and endorse illiberal norms in a way that is sufficiently resistant to change. Such a commitment requires thinking of border coercion as violating an absolute deontological constraint. This, I contend, is implausible. (shrink)

The search for cultural sociology -- New intellectual concepts for cultural sociology -- Social sciences need for the HS paradigm -- Theory of HS and the rules of collective behavioural patterns of influence on people's behaviors -- Culture profile from a different Islamic view -- The Aql-Naql theory of human symbols and the making of cultural sociology -- HS behind human longer lifespan -- Social science illiteracy of the other underdevelopment in post-colonial societies -- The Arab Muslim world set to (...) dialogue with the West : a cultural perspective. (shrink)

The quality of the products coming from different lines of production requires some tests called comparative life tests. For lines having the same facility, the lifetime of the product is distributed by Burr XII, the lifetime distribution, and units are tested under type-I generalized hybrid censoring scheme. The observed censoring data are used under maximum likelihood and the Bayes method to estimate the model parameters. The theoretical results are discussed and assessed through data analysis and Monte Carlo simulation study. Finally, (...) we reported some brief comments obtained from numerical computation. (shrink)

Ubuntu has been defined as a moral quality of human beings, as a philosophy or an ethic, as African humanism, and as a worldview. This paper explores these definitions as conceptual tools for understanding the cultural, educational, and philosophical landscape of post-apartheid South Africa. Key to this understanding is the Althusserian concept of state apparatus. Louis Althusser divides the state apparatus into two forces: the repressive state apparatus (RSA); and the ideological state apparatus (ISA). RSAs curtail the working classes, predominately (...) through direct violence or the threat of violence, whereas ISAs function primarily by ideology, including forms of organised religion, the education system, family units, legal systems, trade unions, political parties, and media. This paper discusses the link between increasing inequality in post-apartheid South Africa and education, with specific reference to Althusser’s ISAs and the abuse of Ubuntu as a subterfuge for socio-economic inequality. (shrink)

This essay was published in the September 2023 edition of Griffith Observer. It is an examination of the curious friendship between writer Aldous Huxley and astronomer Edwin Hubble and its philosophical basis: empiricism. I hope that by consideration of these two thinker''s lives and work light may be shed on each of their ideas and on the 20th century conceptions of empiricism more broadly.

This article exploits the synergy of critical discourse studies and Corpus Linguistics to study the pervasive representation of Islam and Muslims in an approximate 670,000-word corpus of US news media stories published between 2001 and 2015. Following collocation and concordance analysis of the most frequent topics or categories which revolve around the representation of Islam and Muslims in US news stories, the Discourse-Historical Approach to critical discourse analysis was adopted to investigate how the discursive strategies of nomination and predication are (...) used in US news media stories. The findings indicated that, in general, Islam and Muslims are associated with violence, religious radicalism, and Islamic extremist militants. Finally, the article discusses the discursive themes resulting from the analysis of personal pronouns as well as the educational implications of the findings for social studies and multicultural education. (shrink)

Objectivity is one of the most basic and difficult issues in modern and contemporary philosophy. The present paper is devoted to this issue from view- point of Husserl’s transcendental phenomenology. Since perception, particularly sense perception, in view of intentionality, as lowest level of objectivity can act as the base for perceiving the objectivity of other objects, whether real or unreal, it has been discussed in this paper. To do this, objectivity of the sense perception and its role in leading the (...) mind toward essential and ideal objects, and conversely, the role of latter objects in objectivity of the perception itself will be explored. Because the concepts of objectivity and evidence are correlate in Husserl’s philosophy, and since evidence as the self-given manifests itself, from the very beginning, in the lowest level, namely the objects of sense perception, and considering that evidence and objectivity of sense perception concern this lowest level, the critical viewpoint of Husserl’s phenomenology provides a firm and new basis for objectivity if taken at its full competence. (shrink)

This book explores the spiritual potential of faith, mysticism and transcendence in answer to the dangers of a mythologised state and the sacro-sanctification of (liberal) democracy and its rule of law. It searches for a curative for the pathological transformation of these institutions into--so called--political religions. Along this line, it explores the importance of spirituality and transcendence for political legitimacy, democratic participation and international cooperation, law and politics. There being no general agreed-upon definition of 'spirituality', the authors examine what may (...) be seen as 'spiritual' dimensions of the political. These dimensions have in common a focus on transcendence as a vanishing point of rationality and rational justification. This vanishing point may become manifest, for example, in a primordial requisite of becoming an individual person; in responding--in freedom--to the call of theocracy; in the phenomenon of prophecy or political wisdom; in the remaining shards of formerly all-pervasive religious institutions; in tenacious hope for a democracy-to-come; in the courageous resilience and resistance of citizens of 'non-' or 'un-democratic' states; etc."--Page 4 of back cover. (shrink)

I provide an account of the physical appropriate to the task of the physicalist while remaining faithful to the usage of “physical” natural to physicists. Physicalism is the thesis that everything in the world is physical, or reducible to the physical. I presuppose that some version of this position is a live epistemic possibility. The physicalist is confronted with Hempel’s dilemma: that physicalism is either false or contentless. The proposed account of the physical avoids both horns and generalizes a recent (...) proposal by Vicente (2011). My account defines physicalism as the thesis that there are no objects that cannot be described by physical quantities. A dimensional account of physical quantities is given: quantities are determined by measurement procedures. (shrink)

Extant research notes a tendency to propound the idea that female managers are secondary to men. Gender differences constitute an ethical issue and the discursive constructions of gender management are central to research in business ethics. Drawing on evidence gathered from a time–space intersection that has been widely neglected by research in this area, we address whether female business leaders develop gender-stereotypic management styles as well as their propensity to adopt masculine management patterns such as making risky decisions and implementing (...) formal management systems. Our findings suggest that gender-stereotypic management styles are chosen strategically and target-driven, which implies a selective use of masculine and feminine management styles. Furthermore, as part of the masculine approach, female business owners adopt risk-taking decisions and implement formal management systems. Our results provide support for the argument that gender is context dependent and, hence, the findings of this study may be useful for contemporary jurisdictions featuring male-dominated societies and a strong intervention by the State in the economy. (shrink)

In this paper a symmetry argument against quantity absolutism is amended. Rather than arguing against the fundamentality of intrinsic quantities on the basis of transformations of basic quantities, a class of symmetries defined by the Π-theorem is used. This theorem is a fundamental result of dimensional analysis and shows that all unit-invariant equations which adequately represent physical systems can be put into the form of a function of dimensionless quantities. Quantity transformations that leave those dimensionless quantities invariant are empirical and (...) dynamical symmetries. The proposed symmetries of the original argument fail to be both dynamical and empirical symmetries and are open to counterexamples. The amendment of the original argument requires consideration of the relationships between quantity dimensions. The discussion raises a pertinent issue: what is the modal status of the constants of nature which figure in the laws? Two positions, constant necessitism and constant contingentism, are introduced and their relationships to absolutism and comparativism undergo preliminary investigation. It is argued that the absolutist can only reject the amended symmetry argument by accepting constant necessitism. I argue that the truth of an epistemically open empirical hypothesis would make the acceptance of constant necessitism costly: together they entail that the facts are nomically necessary. (shrink)

One of the main arguments intended to show that content externalism undermines the privileged access thesis is the ‘slow switching argument’, originally proposed by Boghossian. In this argument, it is supposed that a subject is unknowingly switched back and forth between Earth and Twin Earth: then it is claimed that, given externalism, when the subject is on Earth thinking that water is wet, he cannot know the content of his thought a priori, for he cannot, by mere reflection, rule out (...) the relevant alternative hypothesis that he is on Twin Earth thinking that twater is wet. One of the controversies surrounding this argument stems from the fact that it is not clear which epistemological principle underlies it. Here, I examine two suggestions made in the literature as to what that underlying principle might be. I argue that neither of these suggested principles is plausible, and thus that the slow switching argument never gets off the ground. (shrink)

Abstract: Tomatoes are part of the major crops in food security. Tomatoes are plants grown in temperate and hot regions of South American origin from Peru, and then spread to most countries of the world. Tomatoes contain a lot of vitamin C and mineral salts, and are recommended for people with constipation, diabetes and patients with heart and body diseases. Studies and scientific studies have proven the importance of eating tomato juice in reducing the activity of platelets in diabetics, which (...) helps in protecting them from developing deadly blood clots. A tomato classification approach is presented with a data set containing approximately 5,266 images with 7 species belonging to tomatoes. The Neural Network Algorithms (CNN), a deep learning technique applied widely in image recognition, is used for this task. (shrink)

Along the lines of a previous work, the geometrical structure of Hibert bundles describing extended quantum free particles is repeated with Galilei external and internal independent symmetries. Then, in order to introduce the interaction, this structure is extended by replacing configuration and momentum spaces by the socelled spaces of trajectories and extended velocity boosts, respectively. These provide representations giving the probability amplitudes for the particle to follow certain trajectories. The interaction can be introduced in the transformation law from functions on (...) the space of trajectories (free dynamics) to functions on spacetime (intracting dynamics). This transformation law, which makes use of a universal distribution, is seen as a functional in our work according to a quantum functional theory which generalizes the ideas of de Broglie. Intertwining of induced representations gives the free propagator in the space of trajectories and, henceforth, the propagator with interaction in space-time for the extended particle. (shrink)

Norms provide a valuable mechanism for establishing coherent cooperative behaviour in decentralised systems in which there is no central authority. One of the most influential formulations of norm emergence was proposed by Axelrod :1095–1111, 1986). This paper provides an empirical analysis of aspects of Axelrod’s approach, by exploring some of the key assumptions made in previous evaluations of the model. We explore the dynamics of norm emergence and the occurrence of norm collapse when applying the model over extended durations. It (...) is this phenomenon of norm collapse that can motivate the emergence of a central authority to enforce laws and so preserve the norms, rather than relying on individuals to punish defection. Our findings identify characteristics that significantly influence norm establishment using Axelrod’s formulation, but are likely to be of importance for norm establishment more generally. Moreover, Axelrod’s model suffers from significant limitations in assuming that private strategies of individuals are available to others, and that agents are omniscient in being aware of all norm violations and punishments. Because this is an unreasonable expectation, the approach does not lend itself to modelling real-world systems such as online networks or electronic markets. In response, the paper proposes alternatives to Axelrod’s model, by replacing the evolutionary approach, enabling agents to learn, and by restricting the metapunishment of agents to cases where the original defection is observed, in order to be able to apply the model to real-world domains. This work can also help explain the formation of a “social contract” to legitimate enforcement by a central authority. (shrink)

Research suggests that people tend to overweight arguments accompanied by neuroscientific terminology, which is dubbed as the seductive allure of neuroscience explanations (SANE) in the literature. Such an effect might be of particular significance when it comes to physicians and mental health professionals (MHP), given that it has the potential to cause significant bias in their understanding as well as their treatment approaches toward psychiatric symptoms. In this study, we aimed to test the SANE effect among Turkish medical students, and (...) assess its uniqueness by comparing it with a discipline that still maintains an important role in contemporary psychiatric training in Turkey: psychoanalysis. 109 medical students with a basic level of knowledge of psychiatry and clinical neuroscience were asked to rate the credibility of explanations of differing quality (good vs. circular) for psychological phenomena, followed by three types of information: none, neuroscientific (SNI) or psychoanalytical (SPI). Our findings showed that SNI significantly increased the judged quality of explanations for both conditions with the effect being more prominent for circular explanations. On the other hand, SPI had no effect on good explanations but enhanced the judged quality of circular explanations in a level comparable to that of SNI. For the first time, the SANE effect was replicated among medical students and provided preliminary data in favor of a similar effect for psychoanalytically oriented information. (shrink)

al-mujallad 1. al-Iḥsān -- al-shahāmah -- al-mujallad 2. al-ṣabr -- al-waqār -- al-mujallad 3. al-Isāʼah -- sūʼ al-ẓann -- al-mujallad 4. al-Shamātah -- al-Yaʼs wa-al-qunūṭ.

Modern dönemde iletişim ve ulaşımda teknolojinin gelişmesiyle birlikte dünya küçük bir köy haline gelmiştir. Bu dönemde Batı sistemi maneviyatı ve ahireti bırakıp maddiyat ve dünya için belli araç ve gereçleri üreterek modern medya alanına egemen olma gücünü elde etmiştir. Bu durum özellikle İslam’a saldıran söylemlerin tırmanması, dini gruplara saldırıların artması ve İslami içeriklerle savaşın büyümesiyle birlikte İslami medyayla uğraşanların hitap önceliklerini tekrar gözden geçirmelerini gerekli kılmıştır. Aslında bu meydan okumalar İslam medyasının daha önce sıkıntısını yaşadığı ve halen de devam eden (...) sorunlara dayanmaktadır. Medya alanında çalışılabilecek çok sayıda konu bulunmaktadır. Bunlar arasında en az tercih edilen konu ise makâsıd ya da evleviyyât bakış açısı ve makâsıd ictihâdı çerçevesinde medyaya bakma konusudur. Bu çalışmada bu konu araştırma konusu olarak seçilmiştir. Bu konunun seçimi, birtakım varsayımlara dayanmaktadır. En önemlisi de makâsıd ilminin ölçü olması ve evleviyyât fıkhıdır. Bu ölçü genel olarak medya ilminin öncüleri ve özel olarak da İslami medyanın öncüleri için makâsıd bakışını sunabilen bilişsel teorilerin ve yöntemsel imkânların amaçladığı önemli niteliklerden biridir. Böylece makalenin sorusu şu şekilde ifade edilebilir: Ümmetin kalkınmasını, liderliğini ve diğer milletler üzerindeki etkisini gerçekleştirmek amacıyla makasıdü’ş-şerî‘aya dayalı öncelikler fıkhının kuralları, çağdaş medya alanına nasıl uygulanabilir? Bu çalışma iki bölümde ele alınmıştır. Birinci bölümde medya alanındaki öncelikler fıkhı kavramı ve bu alandaki bu fıkhı dikkate almanın delilleri ele alınmıştır. İkinci bölümde öncelikler fıkhının kurallarını modern medya alanına tatbik etme konusu ele alınmıştır. Ayrıca makâsıd kuralları, nevazil fıkhının kuralları ve vesail kuralları olan üç kural çeşidine göre her bir mertebe için örnekler verilmiştir. Bu düşünceyi temellendirmenin birçok yönü bulunmaktadır. Fakat bu konu iki yönden ele alınmıştır. Birincisi medya yönündür. Burada öncelikleri modern medya ilminde düzenleme teorisi ele alınmıştır. İkincisi makâsıd yönüdür. Burada makâsıdü’ş-şeri‘a ilmine dayanan önceliklerin kuralları ele alınmıştır. Bu çalışmada biraz karşılaştırma yöntemi kullanmanın yanı sıra genel olarak niteleme, tahlil ve istinbât yöntemleri kullanılmıştır. Bu çalışma neticesinde makâsıd ilmini medya alanıyla ilgili ictihâdî bakışta işletmenin zaruri olduğuna ve bunun bilimsel bir lüks olmayıp zorunlu olduğu sonucuna varılmıştır. Ayrıca modern İslami düşünce medyasının genel olarak makâsıdü’ş-şeri‘a ölçüleri ve özel olarak da hitap ve medya makâsıdının ölçüleriyle yönlendirmesi gerektiği sonucu elde edilmiştir. Medyanın yakın, orta ve uzak stratejilerini geliştirerek evleviyyât fıkhını işler hale getirmenin zorunlu olduğunu öneriyoruz. Ayrıca medya ve makâsıdü’ş-şeri‘a alanlarında araştırma yapan ve bu ilimlerle meşgul olanların medyayı makâsıd fıkhıyla çerçeveleme ve medya alanında makâsıdı çalıştırma konusunda ortak ciddi çalışmalar yapmalarını öneriyoruz. (shrink)